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Depakote Sprinkle® capsules: Swallow full or sprinkle on to food, like applesauce or pudding and consume quickly. Will not chew the sprinkle capsule or contents.
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Proof indicates that folic acid supplementation previous to conception And through the main trimester of pregnancy decreases the chance for congenital neural tube defects in the final inhabitants [see Use in Unique Populations (eight.1)].
Estrogen-That contains Hormonal Contraceptives Estrogen-made up of hormonal contraceptives may raise the clearance of valproate, which can lead to reduced concentration of valproate and likely amplified seizure frequency.
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When you are setting up on becoming Expecting, notify your health care service provider making sure that he/she can finest manage your drugs.
You are able to check with your healthcare supplier or pharmacist for a listing of these medicines if you are not confident.
Convey to your Health care provider immediately in case you develop into Expecting though taking Depakote. You and your healthcare provider ought to make a decision if you might go on to read more take Depakote while you're pregnant.
Phone a healthcare company immediately When you've got any of those signs and symptoms, particularly when They may be new, even worse, or be concerned you: views about suicide or dying
Contact your healthcare company concerning visits as needed, especially if you happen to be concerned about indications.
There have already been reviews of acute or subacute encephalopathy within the absence of elevated ammonia ranges, elevated valproate levels, or neuroimaging changes. The encephalopathy reversed partly or entirely right after valproate discontinuation.
Absorption/Bioavailability Equal oral doses of Depakote (divalproex sodium) goods and valproic acid capsules supply equivalent portions of valproate ion systemically. Even though the charge of valproate ion absorption may possibly vary Along with the formulation administered (liquid, sound, or sprinkle), disorders of use (e.g., fasting or postprandial) and the method of administration (e.g., whether or not the contents from the capsule are sprinkled on food items or the capsule is taken intact), these discrepancies ought to be of insignificant clinical worth under the continual point out situations obtained in chronic use in the remedy of epilepsy. On the other hand, it is possible that distinctions amid the varied valproate products in Tmax and Cmax might be critical on initiation of cure. For example, in single dose research, the impact of feeding had a better affect on the rate of absorption on the tablet (rise in Tmax from 4 to 8 hours) than within the absorption in the sprinkle capsules (rise in Tmax from 3.3 to four.eight several hours). When the absorption amount with the G.I. tract and fluctuation in valproate plasma concentrations change with dosing program and formulation, the efficacy of valproate being an anticonvulsant in Continual use is unlikely to become affected.
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are Expecting or may well develop into Expecting. DEPAKOTE may well damage your unborn little one. See “2. Depakote could harm your unborn baby” above for more information.